Methods and compositions based on shiga toxin type 2 protein

Details Methods and compositions based on shiga toxin type 2 protein Methods and compositions based on shiga toxin type 2 protein

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) A61K 39/108 (2006.01) A61K 39/40 (2006.01) A61P 37/04 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01) G01N 33/53 (2006.01) C07K 14/25 (2006.01)

Patent

CA 2748873

The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.

La présente invention est basée sur la découverte de l'épitope de la protéine Stx2 correspondant à l'anticorps 11 E1O. La présente invention concerne des compositions incluant des polypeptides partiels de Stx2 incluant l'épitope de l'anticorps monoclonal 11 E1O. La présente invention concerne également des méthodes de production d'anticorps anti-Stx2 spécifiques de l'épitope 11 E1O de la protéine Stx2. En outre, la présente invention concerne des méthodes de traitement d'un sujet présentant ou risquant de développer une pathologie associée à une shiga-toxine (par exemple le syndrome hémolytique et urémique et des pathologies associées à une infection par E. coli et S. dysenteriae) par un polypeptide incluant l'épitope 11 E1O ou par un anticorps anti-Stx2 développé à l'aide des méthodes selon l'invention. En outre, la présente invention concerne la détection de Stx2 dans un échantillon en utilisant les anticorps développés à l'aide des méthodes selon l'invention.

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