Methods and compositions comprising non-natural amino acids

Details Methods and compositions comprising non-natural amino acids Methods and compositions comprising non-natural amino acids

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2626522

Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxy lamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.

La présente invention concerne des procédés de détection d'acides aminés non naturels et de polypeptides qui incluent au moins un acide aminé non naturel. Les acides aminés non naturels, isolés ou faisant partie d'un polypeptide, peuvent inclure un large éventail de fonctionnalités, y compris, mais sans limitation, des groupes oxime, carbonyle et/ou hydroxylamine. L'invention concerne également des polypeptides d'acides aminés non naturels qui sont davantage modifiés après traduction et des procédés de détection de tels polypeptides.

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