A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 31/4045 (2006.01) A61K 31/465 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61P 25/28 (2006.01) C07D 209/32 (2006.01) C07D 401/04 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C40B 30/04 (2006.01) C40B 30/10 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2556830
The present invention comprises novel compositions and methods for the treatment of neurological diseases associated with beta amyloid peptide. In particular, the present invention is directed to A.szlig. fiber solubilization, for the treatment of amyloid-associated diseases such as Alzheimer's disease, and is described herein as being achieved by using small molecules binding to A.szlig. fiber. The present invention further comprises novel methods of designing and screening compositions for the treatment of neurological disease wherein the design aspect comprises the modeling of molecular scaffolds having optimal structural characteristics that enable the development of small molecule compositions of non-peptide nature having desirable solubilization effects on amyloid plaques. In one embodiment, the design of the compounds comprises a molecular structure with three chemical domains that include a melatonin-like domain, a nicotine-like domain and a peptide-like domain for binding to A.szlig..
La présente invention concerne des compositions et des méthodes pour le traitement de maladies neurologiques associées au peptide bêta-amyloïde. Elle concerne en particulier la solubilisation de la fibre A.beta. pour le traitement de maladies associées audit peptide tels que la maladie d'Alzheimer. ceci au moyen de petites molécules qui se lient à la fibre A.beta.. Cette invention porte en outre sur des méthodes de conception et de criblage pour le traitement de maladies neurologiques, l'aspect conception englobant la modélisation d'ossatures moléculaires dotées de caractéristiques structurelles optimales qui permettent le développement de compositions de petites molécules de nature non peptidique exerçant les effets de solubilisation recherchés sur les plaques amyloïdes. Dans un mode de réalisation, les composés sont réalisés selon un structure moléculaire à trois domaines chimiques - domaine de type mélatonine, domaine de type nicotine et domaine de type peptide pour la liaison avec A.beta..
Eliseev Alexey
Lehn Jean-Marie
Nicolau Yves Claude
Ac Immune Sa
Goudreau Gage Dubuc
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