C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/10 (2006.01) A61K 31/155 (2006.01) A61P 35/00 (2006.01) C07C 279/20 (2006.01)
Patent
CA 2724408
Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.
L'invention porte sur de nouveaux lipides cationiques, sur des compositions comprenant les lipides cationiques, et sur des procédés d'utilisation des lipides cationiques. Dans certaines revendications, les lipides cationiques ont une activité cytotoxique et peuvent être utilisés seuls ou en combinaison avec un composé bioactif cytotoxique pour tuer une cellule. Dans certaines de ces revendications, le lipide cationique renforce l'activité cytotoxique du composé bioactif cytotoxique. L'invention porte également sur des procédés de traitement d'un sujet affecté par une maladie ou un état pathologique indésirable, le procédé comprenant l'administration, au sujet, d'un système d'apport comprenant un nouveau lipide cationique. L'invention porte en outre sur des procédés de préparation de systèmes d'administration, comprenant les nouveaux lipides cationiques de l'invention.
Bathula Surendar Reddy
Chen Yunching
Chono Sumio
Hackett Michael
Huang Leaf
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Of North Carolina At Chapel Hill
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