Methods and compositions comprising supramolecular constructs

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01) A61P 25/28 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2556479

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.

L'invention concerne de nouvelles compositions et de nouveaux procédés permettant de choisir des réponses immunitaires élevées, d'anticorps conformationnellement sensibles à rendement spécifique élevé. Ces anticorps reconnaissent des épitopes spécifiques parmi une variété élevée d'antigènes comprenant, entre autres, protéine amyloïde, protéine prion, glycoprotéine P¿170?. Ces nouvelles compositions comprennent des constructions antigéniques supramoléculaires contenant généralement une séquence peptidique, fixée par covalence à une PEG-lysine, ce qui permet d'aboutir à une présentation de peptide modifiée et améliorée. Le procédé de modification unique de l'invention peut être appliqué à une variété de peptides et peut être utilisé, en dernier lieu, dans des formulations thérapeutiques et des vaccins pour des maladies et des troubles tels que la maladie d'Alzheimer.

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