Methods and compositions for activating or inhibiting vegf-d...

A - Human Necessities – 61 – K

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A61K 38/43 (2006.01) A61K 38/48 (2006.01) A61K 38/49 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) C07K 16/22 (2006.01) C12Q 1/25 (2006.01) C12Q 1/37 (2006.01) C12S 3/00 (2006.01)

Patent

CA 2493572

Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a pharmaceutical compositions comprising plasmin. Also disclosed are methods of screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-CD, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.

La présente invention a trait à des procédés d'activation des facteurs de croissance endothélial vasculaire C ou D avec de la plasmine et des procédés de traitement comportant l'administration de compositions pharmaceutiques comprenant de la plasmine. L'invention a également trait à des procédés de criblage pour des inhibiteurs de l'activation des facteurs de croissance par la plasmine, et un procédé de traitement par blocage de l'activation des facteurs de croissance endothélial vasculaire C/D par la plasmine. L'invention a trait en outre à des procédés pour le criblage d'autres protéases qui activent le facteur de croissance endothélial vasculaire C/D, et pour des inhibiteurs d'une telle activation. Enfin, l'invention a trait à des inhibiteurs de l'activité plasminique et des procédés de traitement de patients qui en ont besoin avec lesdits inhibiteurs.

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