Methods and compositions for administering gene therapy vectors

Details Methods and compositions for administering gene therapy vectors Methods and compositions for administering gene therapy vectors

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2213439

A method of reducing immune response during gene therapy is provided which involves co-administration of the viral vector bearing a therapeutic transgene and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.

L'invention concerne une méthode de réduction de la réponse immunitaire pendant une thérapie génique, qui consiste à co-administrer le vecteur viral portant un transgène thérapeutique et un immunomodulateur capable d'inhiber la formation d'anticorps de neutralisation et/ou l'élimination des vecteurs par les lymphocytes T cytotoxiques, par administration répétée.

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