Methods and compositions for administration of trpv1 agonists

Details Methods and compositions for administration of trpv1 agonists Methods and compositions for administration of trpv1 agonists

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61F 13/00 (2006.01) A61K 9/70 (2006.01) A61K 31/045 (2006.01) A61K 31/16 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2522028

Compositions are provided that contain a TRPV 1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

L'invention concerne des compositions contenant un agoniste du TRPV 1, tel que la capsaïcine, et un système de solvants. L'application topique de la composition entraîne une distribution rapide d'agonistes dans le derme et l'épiderme. L'invention concerne également un procédé d'utilisation des compositions permettant de réduire la fonction nociceptive des fibres nerveuses et permettant de traiter les états pathologiques associés à la capsaïcine.

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