Methods and compositions for analysis of urine samples in...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 6/00 (2006.01) C12P 19/34 (2006.01) G01N 33/48 (2006.01) G01N 33/493 (2006.01)

Patent

CA 2479379

The invention comprises novel compositions, systems, and methods for the analysis of biological samples, such as urine samples, in order to diagnose and treat kidney disease, including without limitation, glomerulonephritis, nephrotic syndrome, diabetes, lupus, hypertension, acute tubular necrosis, obstructive disorders of the urinary tract, renal cancers and other diseases or syndromes. In preferred embodiments, the invention comprises the identification of particular genes expressed only in cells of particular clinical or scientific interest in the urinary tract, such as podocytes or proximal tubule cells. Thus, the invention enables non-invasive, rapid and accurate analysis of kidney and urinary tract status and function in many medical diseases and disorders.

La présente invention concerne de nouvelles compositions, de nouveaux systèmes et de nouvelles techniques destinées à l'analyses d'échantillons biologiques, tels que des échantillons d'urine en vue de diagnostiquer et de traiter une maladie rénale, notamment la glomérulonéphrite, le syndrome néphrotique, le diabète, le lupus, l'hypertension, la nécrose tubulaire aiguë, les uropathies obstructives, des cancer du rein et d'autres maladies ou d'autres syndromes. Dans des modes de réalisation préférés de l'invention, cette invention comprend l'identification de gènes particuliers uniquement exprimés dans des cellules d'intérêt clinique ou scientifique particulier des voies urinaires, telles que des podocytes ou des cellules de tubule proximal. Cette invention permet ainsi de réaliser une analyse non invasive, rapide et précise de l'état et du fonctionnement du rein et des voies urinaires dans de nombreux cas de maladies et de pathologies.

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