Methods and compositions for attenuating antibody-mediated...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 35/14 (2006.01) A61M 1/38 (2006.01) A61P 37/06 (2006.01) B01D 15/00 (2006.01)

Patent

CA 2116138

Antibody-mediated xenograft rejection is attenuated by (i) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's cieculation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.

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