Methods and compositions for bi-specific targeting of cd19/cd22

Details Methods and compositions for bi-specific targeting of cd19/cd22 Methods and compositions for bi-specific targeting of cd19/cd22

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 38/39 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2755686

Methods and composition involving genetically engineered targeting conjugates with reversed orientation of VL and VH chains are provided. For example, in certain aspects targeting conjugates comprising VL and VH chains of anti-CD22 and anti-CD19 are described. In a further aspect, the invention provides methods and targeting conjugates comprising therapeutic agents or diagnostic agents for delivery to B cells.

La présente invention concerne des procédés et une composition impliquant des conjugués de ciblage issus du génie génétique avec une orientation inverse des chaînes VL et VH. L'invention concerne par exemple, dans certains aspects, des conjugués de ciblage comprenant les chaînes VL et VH d'anticorps anti-CD22 et anti-CD19. L'invention concerne, dans un autre aspect, des procédés et des conjugués de ciblage comprenant des agents thérapeutiques ou des agents diagnostiques pour la délivrance à des lymphocytes B.

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