Methods and compositions for binding tau and map2c proteins

Details Methods and compositions for binding tau and map2c proteins Methods and compositions for binding tau and map2c proteins

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/775 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170727

A method of combatting Alzheimer's disease which comprises increases the binding of the tau protein in nerve cells of that subject and/or the binding or MAP2c protein in nerve cells of that subject, to either Apolipoprotein E or an Apolipoprotein E fragment capable of binding tau and/or MAP2c. In one embodiment, the method comprises administering the ApoE or ApoE fragment to the subject; in another embodiment, the method comprises administering to the subject a vector capable of entering nerve cells, which vector then upregulates the expression of an ApoE or an ApoE fragment capable of binding tau and/or MAP2c in nerve cells. Compositions useful for carrying out these methods are also disclosed

L'invention se rapporte à un procédé permettant de lutter contre la maladie d'Alzheimer et qui consiste à intensifier la fixation de la protéine tau dans les cellules nerveuses d'un sujet, et/ou à intensifier la fixation de la protéine MAP2c dans les cellules nerveuses du sujet, soit sur l'Apolipoprotéine E soit sur un fragment d'Apolipoprotéine E capable de fixer la protéine tau et/ou MAP2c. Selon un mode de réalisation, le procédé consiste à administrer l'ApoE ou un fragment d'ApoE au sujet; selon un autre mode de réalisation, le procédé consiste à administrer au sujet un vecteur capable de pénétrer dans les cellules nerveuses, ce vecteur améliorant ensuite la régulation de l'expression d'une ApoE ou d'un fragment d'ApoE capable de fixer la protéine tau et/ou MAP2c dans les cellules nerveuses. L'invention se rapporte également à des compositions utiles pour réaliser ces procédés.

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