Methods and compositions for cancer therapy and for...

Details Methods and compositions for cancer therapy and for... Methods and compositions for cancer therapy and for...

C - Chemistry, Metallurgy

07

K

C07K 16/32 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2145382

A method for determining the efficacy of a therapeutic agent, in vitro, for a cancer expressing or overexpressing an onco- gene product is described. The method is particularly useful for determining the efficacy of therapeutic agents that have a binding affinity for cancer that express HER-2/neu. N24, N28 and N29 monoclonal antibodies are described which have been identified by this method. One or more of these antibodies can be used as a therapeutic agent in the treatment of breast, stomach, ovarian or salivary cancers.

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