Methods and compositions for cell-cycle regulation

Details Methods and compositions for cell-cycle regulation Methods and compositions for cell-cycle regulation

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2598607

In some aspects, the invention provides methods and compositions including HTm4, an HTm4 activator, and/or an HTm4 variant to potentiate a KAP phosphatase activity and or inhibit a CDK2 kinase activity. In some embodiments, a functional C- terminal fragment of HTm4 is provided. In other aspects, the invention provides methods and compositions including an HTm4 inhibitor to inactivate or decrease the activation of a KAP phospatase activity and/or activate or relieve the inhibition on a CDK2 kinase activity. Certain aspects of the invention relate to therapeutic compositions and methods for either inhibiting or promoting cell proliferation.

Selon certains aspects, la présente invention concerne des méthodes et des compositions comprenant HTm4, un activateur HTm4 et/ou un variant HTm4 pour potentialiser une activité phosphatase KAP et/ou pour inhiber une activité kinase CDK2. Dans certaines formes de réalisation, un fragment du terminal C fonctionnel de HTm4 est utilisé. Selon d'autres aspects, cette invention concerne des méthodes et des compositions comprenant un inhibiteur HTm4 qui sert à inactiver ou à diminuer l'activation d'une activité phosphate KAP et/ou à activer ou à supprimer l'inhibition d'une activité kinase CDK2. Certains aspects de l'invention se rapportent à des compositions thérapeutiques et à des méthodes d'inhibition ou de stimulation de la prolifération cellulaire.

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