Methods and compositions for combinatoral-based production...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 39/00 (2006.01) A61K 39/116 (2006.01)

Patent

CA 2584249

The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.

L'invention concerne des procédés et des compositions de production rapide de vaccins recombinés multivalents au moyen d'hétérocaryons fongiques filamenteux. L'invention repose sur l'utilisation d'hétérocaryons fongiques filamenteux issus de combinaisons de deux ou plusieurs souches parentales dans lesquelles les molécules d'ADN recombiné codant des variants d'antigènes dérivés d'organismes pathogènes ont été introduites. Les vaccins obtenus sont multivalents.

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