Methods and compositions for conserving and/or preparing an...

Details Methods and compositions for conserving and/or preparing an... Methods and compositions for conserving and/or preparing an...

A - Human Necessities

01

N

A01N 1/02 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2660928

A method of conserving and/or preparing an organ or tissue for transplant for a subject, includes administering to a subject, organ or tissue in need of such treatment an effective amount of a composition including a polypeptide agent including thymosin beta 4 (TB4), an isoform, analogue or derivative of TB4 having biological activity of TB4, an N-terminal variant of TB4 having biological activity of TB4, a C-terminal variant of TB4 having biological activity of TB4, LKKTET or a conservative variant thereof, LKKTNT or a conservative variant thereof, KLKKTET or a conservative variant thereof, LKKTETQ or a conservative variant thereof, TB4 sulfoxide, TB4ala, TB9, TBIO, TB11, TB12, TB13, TB14, TB15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, Dnasel, vilin, fragmin, severin, capping protein, ?-actinin or acumentin, or a stimulating agent that stimulates production of a polypeptide agent as described above, or a conservative variant thereof, in the organ or tissue.

La présente invention concerne un procédé de conservation et/ou de préparation d'un organe ou d'un tissu pour une transplantation sur un sujet, qui comprend l'administration à un sujet, un organe ou un tissu nécessitant un tel traitement, d'une quantité efficace d'une composition comprenant un agent polypeptidique comprenant la thymosine bêta 4 (TB4), une isoforme, un analogue ou un dérivé de TB4 ayant l'activité biologique de TB4, un variant N-terminal de TB4 ayant l'activité biologique de TB4, un variant C-terminal de TB4 ayant l'activité biologique de TB4, LKKTET ou un variant conservateur de celui-ci, LKKTNT ou un variant conservateur de celui-ci, KLKKTET ou un variant conservateur de celui-ci, LKKTETQ ou un variant conservateur de celui-ci, un sulfoxyde de TB4, TB4ala, TB9, TBIO, TB11, TB12, TB13, TB14, TB15, de la gelsoline, une protéine de liaison de la vitamine D (DBP), de la profiline, de la colfitine, de l'adsevertine, de la propomyosine, de la finciline, de la dépactine, du Dnasel, de la viline, de la fragmine, de la séverine, une protéine de coiffage, de la ß-actinine ou de l'acumentine, ou un agent stimulant qui stimule la production d'un agent polypeptidique, ou un variant conservateur de celui-ci, dans l'organe ou le tissu.

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