Methods and compositions for control of bone formation via...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2376933

The invention relates to the method for treatment, diagnosis and prevention of bone disease and comprises methods including inhibiting or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. The invention also relates to screening assays to identify compounds that modulate leptin and/or leptin receptor activity. The invention further relates to gene therapy methods utilizing leptin and leptin-related sequences for the treatment and prevention of bone disease.

L'invention concerne des procédés pour le traitement, le diagnostic et la prévention des maladies osseuses, qui consistent à inhiber ou à augmenter la synthèse de la leptine, la synthèse du récepteur de leptine, la liaison de la leptine au récepteur de leptine, et l'activité de ce récepteur. L'invention concerne également des essais de criblage visant à identifier les composés qui modulent l'activité de la leptine et/ou du récepteur de leptine. L'invention concerne par ailleurs des procédés de thérapie génique reposant sur l'utilisation de la leptine et de séquences associées à la leptine pour le traitement et la prévention des maladies osseuses.

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