Methods and compositions for control of fetal growth via...

Details Methods and compositions for control of fetal growth via... Methods and compositions for control of fetal growth via...

A - Human Necessities

61

K

A61K 38/17 (2006.01)

Patent

CA 2563433

The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.

Une méthode de traitement, de diagnostic et de prévention des maladies liées à la croissance foetale et à l'insuffisance placentaire comprend des procédés qui impliquent l'inhibition ou l'augmentation de la synthèse de la relaxine, de la synthèse du récepteur de la relaxine, de la liaison de la relaxine au récepteur de la relaxine, ainsi que de l'activité du récepteur de la relaxine. Par ailleurs, l'invention concerne des essais de dépistage qui modulent l'activité de la relaxine et/ou du récepteur de la relaxine. L'invention concerne en outre des méthodes de thérapie génique qui font intervenir la relaxine ainsi que des séquences liées à la relaxine dans le traitement et la prévention des maladies liées à la croissance foetale et à l'insuffisance placentaire.

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