Methods and compositions for controlled polypeptide synthesis

Details Methods and compositions for controlled polypeptide synthesis Methods and compositions for controlled polypeptide synthesis

C - Chemistry, Metallurgy

07

K

C07K 1/10 (2006.01) C07K 1/08 (2006.01) C07K 1/107 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2372526

Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

L'invention concerne des méthodes et des compositions destinées à générer des polypeptides présentant des propriétés matérielles variées. Ces méthodes incluent un moyen de production de copolypeptides amphiphiles séquencés autoassemblés et des protocoles associés pour adjoindre des aminoacide-N-carboxyanhydrides (NCAs) à fonction oligo(éthylèneglyco) à des chaînes polyaminoacides. Des méthodes additionnelles incluent un moyen d'adjonction d'un groupe terminal à la terminaison carboxy de la chaîne polyaminoacide par réaction d'un amide d'acide aminé alloc-protégé avec un complexe aux ligands donneur de métal de transition, aux fins de former un métallacycle amido amidate pouvant être utilisé dans d'autres réactions de polymérisation. L'invention concerne en outre de nouvelles compositions qui s'utilisent dans la synthèse et la mise au point de peptides comprenant des métallacycles à cinq et six chaînons contenant amido et des copolypeptides séquencés.

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