C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01)
Patent
CA 2528012
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.
Fondées en partie sur la compréhension des mécanismes par lesquels de petits ARN par exemple des (ARNmi survenant naturellement) rendent silencieux l'ARN de plantes, des règles avaient été établies de façon à déterminer, par exemple, le degré de complémentarité requis entre un agent médiateur par ARNi et sa cible, c'est-à-dire, si des mésappariements sont tolérés, le nombre de mésappariements tolérés, l'effet de la position de ces mésappariements, etc.. Ces règles sont utiles, en particulier, dans la conception d'un agent médiateur par ARNi amélioré qui permet une commande plus exacte de l'efficacité permettant de rendre silencieux l'ARN.
Tang Guiliang
Zamore Phillip D.
Borden Ladner Gervais Llp
University Of Massachusetts
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