A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/36 (2006.01)
Patent
CA 2440087
Tissue is crosslinked with compositions that include bridges. In some embodiments, the tissue includes linkers that bond to the tissue and bridges that connect two or more of the linkers. In other embodiments, bridges connect two or more modified sites in a modified tissue. The use of bridges in the crosslinking methods more modified sites in a modified tissue. The use of bridges in the crosslinking methods more readily forms crosslinks, particularly between different polypeptides in the tissue. The use of bridges can allow for greater modulation of the degree of crosslinking of a tissue.
Selon cette invention, un tissu est réticulé au moyen de compositions comprenant des ponts. Selon certaines réalisations, le tissu comprend des lieurs qui se lient au tissu et des ponts qui raccordent au moins deux lieurs. Selon d'autres réalisations, les ponts raccordent au moins deux sites modifiés d'un tissu modifié. L'utilisation des ponts dans les procédés de réticulation permet de former plus facilement des liaisons, notamment entre différents polypeptides du tissu. L'utilisation des ponts permet une plus grande modulation du degré de réticulation d'un tissu.
Mirsch M. William II
Ogle Matthew F.
Robic
St. Jude Medical Inc.
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