Methods and compositions for delivery of therapeutic agents...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01)

Patent

CA 2280957

The invention provides conjugates of negatively charged peptide oligomers with therapeutic agents, moieties capable of recruiting endogenous bone-affecting agents, or imaging agents, useful for delivering the agents to bone tissue or calcified masses, and the methods of use thereof. The negatively charged peptide oligomers bind strongly but reversibly to bone tissue and calcified masses with a controllable affinity and retention time on the tissue or mass.

Cette invention concerne des conjugués d'oligomères peptidiques chargés négativement et d'agents thérapeutiques, des fractions capables de recruter des agents endogènes affectant les os ou des agents d'imagerie qui sont utiles pour apporter les agents aux tissus osseux ou à des masses calcifiées, ainsi que leurs procédés d'utilisation. Les oligomères peptidiques chargés négativement se lient de manière forte mais réversible au tissu osseux et aux masses calcifiées avec une affinité et un temps de rétention régulables sur le tissu ou la masse.

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