C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 39/04 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/08 (2006.01) C12N 15/31 (2006.01) C12P 7/64 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2162868
The embodiments of the invention are based upon the identification and characterization of genes that determine mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. These genes, termed inhA, encode a polypeptide, InhA, that is the target of action of mycobacteria for isoniazid. The sequences of wild-type INH-sensitive as well as allelic or mutant INH-resistant inhA genes and their operons are provided. Also provided are isolated InhA polypeptides of both INH-resistant and the INH-sensitive types.
Banerjee Asesh
Collins Desmond Michael
de Lisle Geoffrey William
Jacobs William R. Jr.
Wilson Theresa Mary
Agresearch New Zealand Pastoral Agriculture Research Institute Ltd.
Albert Einstein College Of Medicine Of Yeshiva University
Banerjee Asesh
Collins Desmond Michael
de Lisle Geoffrey William
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