C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 31/70 (2006.01) A61K 39/04 (2006.01) C07H 21/00 (2006.01) C07K 14/35 (2006.01) C12N 9/08 (2006.01) C12N 15/11 (2006.01) C12Q 1/18 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2210378
The embodiments of the invention are based upon the identification and characterization of an operon that determines mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. This operon, termed <u>ahpCF</u>, encodes polypeptides, AhpC and AhpF, which likely combine to form an active alkyl hydroperoxide reductase enzyme that may either be a direct target for INH or act to confer INH resistance. The sequence of the mutant <u>ahpCF</u> operon is provided, showing that INH resistance can be conferred by a mutation in the promoter region. Also provided are polynucleotides and polypeptides that are useful in diagnosis and treatment.
Les modes de réalisation de l'invention sont basés sur l'identification et la caractérisation d'un opéron déterminant la résistance mycobactérienne à l'antibiotique isoniaside (INH) et ses analogues. Cet opéron, appelé <u>ahpCF</u>, code des polypeptides, AhpC et AhpF, lesquels sont susceptibles de se combiner pour former une réductase d'hydropéroxyde d'alkyle active pouvant être soit une cible directe pour l'INH soit agir pour conférer une résistance à l'INH. L'invention concerne également la séquence de l'opéron <u>ahpCF</u> mutant illustrant que la résistance à l'INH peut être conférée par une mutation dans la région promotrice. L'invention concerne également des polynucléotides ainsi que des polypeptides utiles dans le diagnostic et le traitement.
Collins Desmond Michael
Wilson Theresa
Borden Ladner Gervais Llp
New Zealand Pastoral Agriculture Research Institute Limited
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