C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2488382
In certain aspects, the invention provides isolated SLC5A8 (also referred to as Huil) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.
Dans certains aspects, cette invention concerne des mol~cules d'acide nucl~ique isol~es SLC5A8 (aussi appel~es Hui1), codant pour de nouveaux ~l~ments symporteurs de solut~s de sodium. Ladite invention concerne ~galement des mol~cules d'acide nucl~ique antisens, des vecteurs d'expression recombinants contenant lesdites mol~cules d'acide nucl~ique SLC5A8, des cellules hÙtes ~ l'int~rieur desquelles ces vecteurs d'expression ont ~t~ introduits ainsi que des animaux transg~niques non humains dans lesquels un gne SLC5A8 a ~t~ introduit ou interrompu. Cette invention concerne en outre des prot~ines SLC5A8 isol~es, des prot~ines hybrides, des peptides antig~niques et des anticorps anti-SLC5A8 ainsi que des m~thodes diagnostiques utilisant des compositions de ladite invention. Dans d'autres aspects, cette invention concerne des m~thodes et des compositions pour d~tecter et traiter un cancer associ~ ~ SLC5A8. La m~thylation diff~rentielle des s~quences nucl~otidiques SLC5A8 a ~t~ observ~e dans des cancers associ~s ~ SLC5A8, tels que les cancers du colon, du sein, de la thyro~de ou de l'estomac.
Borden Ladner Gervais Llp
Case Western Reserve University
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