Methods and compositions for detecting receptor ligand mimetics

G - Physics – 01 – N

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G01N 33/50 (2006.01) A61K 31/66 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2669012

A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules.

L'invention concerne un procédé permettant de déterminer l'utilité de petites molécules en tant que substituts fonctionnels (mimétiques) pour des ligands de récepteurs protéiques. Le procédé repose sur l'utilisation d'essais biologiques cellulaires sur un réseau systématique de composés, comprenant des ligands connus de récepteurs protéiques et d'autres molécules biologiquement actives, pour déterminer si une petite molécule proposée est un équivalent fonctionnel d'un ligand de récepteur et présente une utilité thérapeutique en tant qu'agent pharmaceutiquement approprié et utile, soit seule, soit en combinaison avec d'autres molécules.

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