C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 50/14 (2006.01) C07H 21/00 (2006.01) C07K 16/44 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2452690
An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are disclosed, along with cells for making such antibodies. Methods of making and using such antibody microarrays are also disclosed.
L'invention concerne un microréseau d'anticorps comprenant une pluralité d'anticorps immobilisés sur un substrat, chaque anticorps se liant spécifiquement à un oligomère synthétique (p. ex. un oligonucléotide ou un oligopeptide) auquel est lié un groupe protecteur organique de façon covalente, l'anticorps ne se liant pas à cet oligomère synthétique si le groupe protecteur organique n'est pas lié de façon covalente à celui-ci. L'invention concerne par ailleurs des procédés de production et d'utilisation de ces anticorps, ainsi que des cellules pour produire ces anticorps. L'invention concerne enfin des procédés de production et d'utilisation de ce type de microréseau d'anticorps.
Mitchell Lloyd G.
Pearce Christopher D. J.
Marks & Clerk
Proteome Sciences Plc
Veri-Q Inc.
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