C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 49/00 (2006.01) C12N 15/65 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2247995
Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that encodes a reporter molecule and a second p53 binding polynucleotide sequence that is operably linked to the first polynucleotide sequence such that binding of p53 to the second polynucleotide sequence causes the expression of the reporter molecule which can be detected or quantified.
L'invention concerne des procédé et des compositions pour déterminer l'état des suppresseurs de tumeurs de cellules, de préférence, l'état des p53 de cellules tumorales, et de préférence <u>in vivo</u>, au moyen d'un produit de recombinaison consistant en une première séquence polynucléotidique codant une molécule reporter et une seconde séquence polynucléotidique fixant p53 et liée de manière active à la première séquence de sorte que la fixation de p53 à la seconde séquence polynucléotidique provoque l'expression de la molécule reporter qui peut être détectée ou quantifiée.
Fetherstonhaugh & Co.
Onyx Pharmaceuticals Inc.
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