Methods and compositions for diagnosing carcinomas

Details Methods and compositions for diagnosing carcinomas Methods and compositions for diagnosing carcinomas

G - Physics

01

N

G01N 33/574 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2369433

The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.

L'invention concerne des compositions et des techniques servant à la détection d'une affection maligne, et porte sur la découverte de formes solubles de polypeptides de mésothéline, y compris l'antigène en rapport avec la mésothéline (MRA). L'invention concerne particulièrement une séquence d'acides nucléiques codant pour le MRA et un variant de MRA. L'invention concerne également une technique de dépistage d'une affection maligne chez un patient, consistant à détecter la réactivité d'un anticorps spécifique d'un polypeptide de mésothéline avec une molécule naturellement soluble contenue dans un échantillon prélevé chez le patient, et à cribler par hybridation à l'aide d'une séquence de nucléotide MRA. L'invention concerne en outre d'autres avantages connexes.

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