G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2740923
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin- 1, soluble Angiopoietin-1 receptor, C-X-C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin- 1, C-C motif chemokine 22, C-C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.
La présente invention concerne des procédés et des compositions pour la surveillance, le diagnostic, le pronostic et la détermination de régimes de traitement chez des sujets souffrant de ou suspectés davoir une lésion rénale. En particulier, linvention concerne lutilisation dessais qui détectent un ou plusieurs marqueurs choisis dans le groupe constitué de lantigène CD44 soluble, langiopoïétine-1, le récepteur dangiopoïétine-1 soluble, le motif 5 de chimiokine C-X-C, lendogline soluble, le transducteur de signal calcium tumoral soluble 1, lérythropoïétine, la fractalkine soluble, lhème oxygénase 1, le récepteur dinterleukine-1 soluble de type II, la sous-unité alpha de récepteur dinterleukine-6 soluble, la lymphotactine, la lymphotoxine alpha, la stromélysine-1, la chimiokine 22 à motif C-C, la chimiokine 5 à motif C-C, et la thrombospondine-1 en tant que biomarqueurs diagnostiques et pronostiques dans des lésions rénales.
Anderberg Joseph
Gray Jeff
Mcpherson Paul
Nakamura Kevin
Astute Medical Inc.
Perley-Robertson Hill & Mcdougall Llp
LandOfFree
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