Methods and compositions for diagnosis and prognosis of...

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G01N 33/48 (2006.01)

Patent

CA 2735587

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha- 1-antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

La présente invention concerne des méthodes et des compositions permettant la surveillance, le diagnostic, le pronostic et la détermination de schémas thérapeutiques chez des patients souffrant ou susceptibles de souffrir dune lésion rénale. En particulier, linvention concerne lutilisation de dosages qui détectent un marqueur ou plus sélectionnés dans le groupe constitué par la p-sélectine soluble, lhomologue de la protéine NOV, le récepteur du facteur de croissance épidermique soluble, la nétrine-4, lhaptoglobine, la protéine de stress bêta-1, lantitrypsine alpha-1, lélastase leucocytaire, le membre 6 de la superfamille des récepteurs du facteur de nécrose tumorale soluble, le membre 6 de la superfamille des ligands du facteur de nécrose tumorale soluble, la molécule dadhésion intercellulaire 2 soluble, la caspase-3 active, et la molécule soluble dadhésion aux cellules endothéliales dérivées des plaquettes comme marqueurs biologiques pronostics des lésions rénales.

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