Methods and compositions for diagnosis and prognosis of...

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G01N 33/48 (2006.01) C12Q 1/42 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2751424

Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury In particular, disclosed are assays that detect one or more markers selected from the group consisting of Prostatic acid phosphatase, Lactotransfenin, Soluble erythropoietin receptor, Von Willebrand factor, Soluble endothelial protein C receptor, and Beta-2- glycoprotem 1 as diagnostic and prognostic biomarkers in renal injuries.

La présente invention concerne des procédés et compositions permettant de surveiller, diagnostiquer, de pronostiquer et de définir un schéma thérapeutique pour des sujets chez qui on a constaté ou on soupçonne une lésion rénale. L'invention concerne plus particulièrement des essais permettant de détecter un ou plusieurs marqueurs choisis dans le groupe constitué de la phosphatase acide de la prostate, de la lacrotransférrine, du récepteur de l'érythropoïétine soluble, du facteur de von Willebrand, du récepteur de la protéine C endothéliale soluble, et de la bêta-2-glycoprotéine 1, qui constituent autant de biomarqueurs de diagnostic et de pronostic de lésions rénales.

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