Methods and compositions for diagnosis and treatment of...

C - Chemistry – Metallurgy – 12 – Q

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Details

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/82 (2006.01) C12N 5/08 (2006.01) C12P 19/34 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2351627

The present invention relates to methods for treating and preventing cancer by modifying the expression of ets2 gene expression or the activity of the gene product. The invention also relates to sensitizing cancer cells to chemotherapeutic or radiotherapeutic agents. Ets2 gene expression and/or activity of the gene product can be modulated using antisense ets2 nucleic acids and/or modified ets2 proteins. The present invention also provides pharmaceutical compositions which comprise antisense ets2 nucleic acid, and nucleic acid that encode modified ets2 proteins and/or modified ets2 proteins.

La présente invention se rapporte à des méthodes permettant de traiter et de prévenir le cancer et consistant à modifier l'expression du gène ets2 ou l'activité du produit génique associé. Cette invention se rapporte également à la sensibilisation de cellules cancéreuses à des agents chimiothérapeutiques ou radiothérapeutiques. Il est possible de moduler l'expression du gène ets2 et/ou l'activité du produit génique à l'aide d'acides nucléiques de ets2 antisens et/ou de protéines ets2 modifiées. La présente invention se rapporte également à des compositions pharmaceutiques qui contiennent des acides nucléiques du gène ets2 antisens, à des acides nucléiques qui codent des protéines ets2 modifiées et/ou à des protéines ets2 modifiées.

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