C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 1/20 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2283394
The present invention relates to a novel gene, CaSm, that is highly expressed in cancer tissues and cell lines, especially pancreatic cancer. The full length cDNA of CaSm encodes a protein of 133 amino acids. CaSm contains the two Sm motifs found in the common snRNP proteins, with the greatest homology to the Sm G protein (60 % similarity). The present invention further encompasses CaSm peptides, fusion proteins, host cell expression systems, antibodies to CaSm, antisense CaSM molecules, and compounds that modulate CaSm gene expression or CaSm activity. Antisense CaSm RNA is able to alter the transformed phenotype of pancreatic cancer cells by reducing their ability to form large colonies in soft agar when compared to untransfected cells. The present invention also encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
L'invention concerne un nouveau gène, le CaSm, qui est hautement exprimé dans les tissus et les lignées cellulaires cancéreux, notamment dans le cancer du pancréas. L'ADN pleine longueur de CaSm code une protéine à 133 acides aminés. CaSm contient les deux motifs Sm que l'on trouve dans les protéine SnRNP communes, qui présentent l'homologie la plus grande avec la protéine Sm G (60 % de similarité. L'invention se rapporte à des peptides, des protéines de fusion, des systèmes d'expression de cellules hôtes de CaSm, des anticorps dirigés contre CaSm, des molécules CaSM antisens et des composés qui modulent l'expression du gène CaSm ou son activité. L'ARN de CaSm antisens est capable de modifier le phénotype transformé des cellules du cancer du pancréas en réduisant leur capacité à former des colonies importantes dans l'agar doux en comparaison avec les cellules non transfectées. L'invention porte encore sur des procédés de diagnostic de maladies, de dosage de médicament et de traitement du cancer.
Baron Paul L.
Papas Takis S.
Schweinfest Clifford W.
Watson Dennis K.
Musc Foundation For Research Development
Osler Hoskin & Harcourt Llp
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