Methods and compositions for diagnosis of hepatoma

Details Methods and compositions for diagnosis of hepatoma Methods and compositions for diagnosis of hepatoma

G - Physics

01

N

G01N 33/574 (2006.01) C07K 2/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2321160

The present invention provides methods and compositions for screening, diagnosis and prognosis of hepatoma, for monitoring the effectiveness of hepatoma treatment, and for drug development. Hepatoma-Diagnostic Features (HFs), detectable by two-dimensional electrophoresis of serum or plasma are described. The invention further provides Hepatoma-Diagnostic Protein Isoforms (HPIs) detectable in serum or plasma, preparations comprising isolated HPIs, antibodies immunospecific for HPIs, and kits comprising the aforesaid.

L'invention concerne des procédés et des compositions permettant de rechercher, de diagnostiquer un carcinome hépatocellulaire et d'établir un pronostic pour ce dernier, de vérifier l'efficacité d'un traitement du carcinome hépatocellulaire, et mettre au point des médicaments. L'invention concerne également des caractères pathognomoniques du carcinome hépatocelluaire qui peuvent être détectés par une électrophorèse bidimensionnelle du sérum ou du plasma. L'invention concerne en outre des isoformes de protéines pour le diagnostic du carcinome hépatocellulaire (HPI: Hepatoma-Diagnostic Protein Isoforms) détectables dans le sérum ou le plasma, des préparation contenant les HPI isolés, des anticorps pour les HPI immunospécifiques, et des ensembles comprenant ces différents éléments.

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