C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C12N 15/10 (2006.01) C12N 15/64 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2419961
Methods as depicted in figure 3, for directed evolution are described where genetic elements are randomly cleaved to permit the deletion or addition of polynucleotides or both to create a library of related genetic elements with additions or deletions. Corresponding library populations are also described. These processes allow a significant sampling of sequence space which is necessary for directed evolution of genes. Further described are methods for effecting very small nucleotide deletions in genetic elements of interest.
L'invention concerne des méthodes illustrées par la figure destinées à l'évolution dirigée, dans lesquelles des éléments génétiques sont clivés de façon aléatoire pour permettre la délétion ou l'addition de polynucléotides ou l'un et l'autre afin de créer une banque d'éléments génétiques libérés avec des additions ou des délétions. L'invention concerne également des populations de banques correspondantes. Ces processus permettent un échantillonnage significatif de l'espace de séquence nécessaire à une évolution dirigée de gènes. En outre, l'invention concerne des méthodes permettant d'effectuer de très petites délétions de nucléotides dans des éléments génétiques étudiés.
Fetherstonhaugh & Co.
Integrigen Inc.
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