C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2731797
The invention provides antibody arrays specific for target antigens. Methods for discovery and compositions comprising native human antibodies, arrays comprising such antibodies, immortalized B cells expressing such antibodies and non-immortalized B cell libraries comprising B cells expressing such antibodies are provided. The invention provides a method for screening monoclonal antibodies for functional effects on cell surface molecules such as receptors using antibody repertoire arrays specific for target cell surface molecules. Functional antibodies directed to a target and therapeutics derived from such antibodies are also provided. High throughput and parallel screening for potentially therapeutic antibodies are provided. Antibodies directed to functional epitope clusters corresponding to a target and vaccines and therapeutics derived from such antibodies are also provided.
La présente invention concerne des puces à anticorps spécifiques dantigènes cibles. Linvention concerne également des procédés de découverte et des compositions comprenant des anticorps humains natifs, des puces comprenant de tels anticorps, des lymphocytes B immortalisés exprimant de tels anticorps et des banques de lymphocytes B non immortalisés comprenant des lymphocytes B exprimant de tels anticorps. Linvention concerne un procédé de criblage danticorps monoclonaux à la recherche deffets fonctionnels sur des molécules de la surface cellulaire telles que des récepteurs en utilisant des puces à anticorps spécifiques de molécules de la surface cellulaire cibles. Linvention concerne également des anticorps fonctionnels dirigés contre une cible et des produits thérapeutiques dérivés de tels anticorps. Linvention concerne le criblage haut débit et parallèle à la recherche danticorps potentiellement thérapeutiques. Linvention concerne également les anticorps dirigés contre des groupes dépitopes fonctionnels correspondant à une cible et des vaccins et produits thérapeutiques dérivés de tels anticorps.
Ridout & Maybee Llp
Theraclone Sciences
LandOfFree
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