Methods and compositions for engineering of attenuated vaccines

Details Methods and compositions for engineering of attenuated vaccines Methods and compositions for engineering of attenuated vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/155 (2006.01) A61K 39/21 (2006.01) A61K 39/255 (2006.01) A61K 39/265 (2006.01) A61K 39/29 (2006.01) C12N 1/36 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2377084

This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.

Cette invention porte sur des vaccins atténués et sur des procédés visant à obtenir ces vaccins. Les vaccins de cette invention comprennent des parasites bactériens et viraux de recombinaison et autres organismes qui sont mis au point de façon à être fortement atténués sans que le vaccin perde son efficacité. Ces procédés consistent à créer des bibliothèques d'acides nucléiques de recombinaison (à savoir, des génomes entiers ou partiels, ou en particulier des acides nucléiques) qui sont introduits dans les virus ou autres organismes composant le vaccin, puis à rechercher systématiquement et/ou sélectionner ces virus ou organismes qui ont été atténués.

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