Methods and compositions for enhanced delivery of...

Details Methods and compositions for enhanced delivery of... Methods and compositions for enhanced delivery of...

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 39/00 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2730178

The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.

La présente invention concerne des compositions et des procédés favorisant l'administration, à travers des jonctions occlusives, de grosses macromolécules (c'est-à-dire d'une taille supérieure à 10 kDa), par exemple des polypeptides liant un antigène. Lesdits procédés et compositions se révèlent particulièrement utiles pour l'administration, en direction du SNC, de polypeptides thérapeutiques liant des antigènes, par voie intranasale, en vue du traitement de troubles neurologiques.

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