Methods and compositions for enhancing angiogenesis

Details Methods and compositions for enhancing angiogenesis Methods and compositions for enhancing angiogenesis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 7/00 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/18 (2006.01) C12N 15/19 (2006.01)

Patent

CA 2423656

This invention relates generally to the field of angiogenesis. In particular, the invention provides a method for enhancing angiogenesis, which method comprises administering an effective amount of an integrin binding pro- angiogenic agent or an integrin antagonist to a mammal, wherein angiogenesis is desirable, thereby enhancing angiogenesis in said mammal. The invention also provides isolated, angiogenic proteins or peptides or isolated nucleic acids encoding the angiogenic proteins or peptides. Combinations and methods for enhancing angiogenesis are further provided.

La présente invention concerne d'une façon générale l'angiogenèse, et plus particulièrement un procédé permettant de renforcer l'angiogenèse. Ce procédé implique, en cas de nécessite d'angiogenèse, l'administration à un mammifère d'une quantité suffisante d'un pro-angiogène se liant à l'intégrine ou d'un antagoniste de l'intégrine, ce qui aboutit à un renforcement de l'angiogenèse chez ce mammifère. L'invention concerne également des protéines ou des peptides angiogènes, ou des acides nucléiques isolés codant ces protéines ou peptides angiogènes. L'invention concerne enfin des combinaisons et des procédés destinés à renforcer l'angiogenèse.

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