A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/40 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2410827
The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced. Compositions and kits for enhancing the efficiency of delivery of a nucleic acid to a cell are also included.
L'invention concerne des procédés et des compositions utiles pour augmenter l'efficacité de libération d'un acide nucléique dans une cellule. La cellule est, de préférence, une cellule de mammifère. Ledit procédé consiste à fournir à une cellule un agent capable d'augmenter la permissivité cytosquelettique de la cellule à la transfection. Ledit procédé consiste également à fournir à la cellule un système de libération d'acide nucléique pour la transfection de cette dernière, l'efficacité de la libération d'un acide nucléique dans la cellule étant augmentée. Des compositions et des kits pour augmenter l'efficacité de libération d'un acide nucléique dans une cellule sont également décrits.
Jones Peter L.
Levy Robert J.
Li Quanyi
Bereskin & Parr
Children's Hospital Of Philadelphia
Jones Peter L.
Levy Robert J.
Li Quanyi
LandOfFree
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