C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01)
Patent
CA 2613283
The present invention provides methods and compositions for expressing a protease or pro-protease in cells that do not naturally express the protease or pro-protease. The invention further provides methods of producing viruses, e.g., influenza viruses, in such cells. The invention also provides methods for increasing the titer of influenza viruses grown in cells that express such a heterologous protease or pro-protease. Additionally, the invention provides a protease from Streptomyces griseus useful in the methods and compositions.
L'invention se rapporte à des procédés et à des compositions permettant d'exprimer une protéase ou une pro-protéase dans des cellules qui n'expriment pas naturellement la protéase ou la pro-protéase. L'invention concerne également des procédés de production de virus, par exemple de l'influenzavirus, dans lesdites cellules. L'invention concerne également des procédés permettant d'augmenter le titre d'influenzavirus qui se sont développés dans des cellules exprimant ladite protéase ou pro-protéase hétérologue. L'invention concerne également une protéase issue de Streptomyces griseus et qui est utile dans les méthodes et les compositions de l'invention.
Duke Gregory
Hazari Nisha
Kemble George
Mo Chengjun
Young James
Medimmune Vaccines Inc.
Smart & Biggar
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