C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A01K 67/00 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2435631
The present invention generally relates to promoters, enhancers and other regulatory elements of smooth muscle cells ("SMC"). The invention more particularly relates to methods for the targeted knockout, or over-expression, of genes of interest within smooth muscle cells or within a subtype of smooth muscle cells. The invention further relates to methods of conferring polynucleotide expression in vivo specifically in smooth muscle cells or in subtypes of smooth muscle cells.
L'invention concerne en règle générale des promoteurs, des amplificateurs et autres éléments régulateurs de cellules de muscle lisse. L'invention concerne plus particulièrement des procédés pour l'inactivation ou la surexpression ciblée de gènes visés, dans les cellules de muscle lisse ou dans un sous-type de ces cellules. L'invention concerne également des procédés pour l'expression de polynucléotides in vivo spécifiquement dans les cellules de muscle lisse ou dans des sous-types de ces cellules.
Manabe Ichiro
Owens Gary K.
Fetherstonhaugh & Co.
Setagon Inc.
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