Methods and compositions for extending the life span and...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 45/00 (2006.01) A61P 39/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2495185

The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

L'invention concerne des méthodes et des compositions destinées à moduler la durée de vie de cellules eucaryotes et procaryotes, et à protéger les cellules contre certains stress, tels que le choc thermique. Une méthode consiste à moduler le flux de la voie de récupération de NAD+ dans la cellule, par exemple par modulation du niveau ou de l'activité d'une ou de plusieurs protéines sélectionnés dans le groupe constitué par NPT1, PNC1, NMA1 et NMA2. Une autre méthode consiste à moduler le niveau de nicotinamide dans la cellule.

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