C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/071 (2010.01) A61K 31/7052 (2006.01) A61K 38/45 (2006.01) C12N 1/16 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) C12N 9/10 (2006.01)
Patent
CA 2595495
The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPTl, PNCl, NMAl and NMA2. Another method comprises
Procédés et compositions permettant de moduler la durée de vie des cellules eucaryotes et procaryotes, et de protéger les cellules contre certains types de stress, par exemple le choc thermique. Selon un procédé, on module le flux du trajet de récupération NAD+ dans la cellule, par exemple en modulant le niveau ou l'activité d'une ou plusieurs protéines pouvant être NPT1, PNC1, NMA1 et NMA2. Selon un autre procédé, on module le niveau de nicotinamide dans la cellule.
Bitterman Kevin J.
Sinclair David A.
President And Fellows Of Harvard College
Riches Mckenzie & Herbert Llp
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