C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 14/525 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2293829
This invention relates to novel glycoprotein glycoform preparations comprising the substantially homogenous glycoprotein glycoforms. More particularly the invention relates to substantially homogenous glycoprotein preparations comprising a particular Fc glycan and methods for producing, detecting, enriching and purifying the glycoforms. The invention further relates to immunoglobulins and especially antibodies comprising a CH2 domain having a particular glycan. Provided are compositions including pharmaceutical compositions, methods of using the preparations as well as articles of manufacture comprising the preparations.
L'invention a trait à de nouvelles préparations de glycoformes glycoprotéiques contenant les glycoformes glycoprotéiques sensiblement homogènes. L'invention concerne plus particulièrement des préparations de glycoprotéines sensiblement homogènes renfermant un glycanne Fc, ainsi que des procédés permettant de fabriquer, déceler, enrichir et purifier les glycoformes. En outre, l'invention se rapporte à des immunoglobulines et, en particulier, à des anticorps renfermant un domaine CH2 contenant un glycanne particulier. L'invention concerne enfin des compositions, notamment des compositions pharmaceutiques, des procédés d'utilisation de ces préparations ainsi que des produits manufacturés renfermant ces préparations.
Raju T. Shantha
Genentech Inc.
Gowling Lafleur Henderson Llp
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