C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/05 (2006.01) C07K 14/52 (2006.01) C07K 14/535 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2318663
Methods and compositions are described for the efficient delivery and expression of recombinant polynucleotides in animal cells in vitro or in vivo. In particular, a comprehensive approach of non-viral gene delivery is provided that has been optimized with regards to the vectors delivered, maximizing the amount and duration of gene expression, and methods of conditioning the patient to enhance the efficiency of gene delivery. The described methods find application in both gene therapy, and the functional analysis of cloned gene products in vivo.
La présente invention concerne des méthodes et des procédés permettant l'administration et l'expression efficaces de polynucléotides de recombinaison dans des cellules animales, in vitro ou in vivo. Cette invention concerne particulièrement une approche exhaustive de la distribution des gènes non viraux optimisée par rapport aux vecteurs administrés, la maximalisation de la quantité et de la durée de l'expression génique, ainsi que des méthodes de conditionnement du patient afin d'améliorer l'efficacité de l'administration génique. Les méthodes de cette invention peuvent être appliquées à la fois en thérapie génique et dans l'analyse fonctionnelle des produits géniques clonés in vivo.
California Pacific Medical Center
Osler Hoskin & Harcourt Llp
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