Methods and compositions for gene inactivation

Details Methods and compositions for gene inactivation Methods and compositions for gene inactivation

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2651499

Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

La présente invention concerne des procédés et compositions destinés à l'inactivation des gènes CCR-5 au moyen de nucléases doigts de zinc ou ZFN (Zinc Finger Nucleases) comprenant une protéine doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. L'invention concerne également des polynucléotides codant ces ZFN, des vecteurs comprenant des polynucléotides codant les ZFN tels que des vecteurs adénoviraux (Ad), et des cellules comprenant des polynucléotides codant des ZFN et/ou des cellules comprenant des ZFN.

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