Methods and compositions for generating human monoclonal...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/00 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2398284

The present invention provides a method for generating human monoclonal antibodies, especially those that are specific for surface antigens representative of a particular cell type. The present invention also includes populations of monoclonal antibodies produced by the invention methods, populations of polynucleotides comprising sequences encoding the immunoglobulins or fragments thereof, which are capable of binding to antigens representative of a cell type of interest.

La présente invention concerne une méthode pour générer des anticorps monoclonaux humains en particulier ceux qui sont spécifiques à des antigènes de surface représentatifs d'un type cellulaire particulier. La présente invention concerne également des populations d'anticorps monoclonaux produits par les méthodes de l'invention, des populations de polynucléotides contenant des séquences codant les immunoglobulines ou des fragments de celles-ci, lesquelles sont capables de se fixer à des antigènes représentatifs d'un type cellulaire d'intérêt.

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