Methods and compositions for healing and repair of...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01) A61L 27/22 (2006.01) A61L 27/24 (2006.01) A61L 27/36 (2006.01) C07K 14/51 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220555

Methods and compositions are provided for the treatment of defects and disease involving the functional attachment of connective tissue, such as tendon or ligament, to bone. Preferred methods comprise administering a composition containing a bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional attachment between the connective tissue and bone, such that minimal fibrous or granulation tissue is formed at the interface between the regenerated bone and connective tissue. The method and composition are useful for augmenting tissue grafts in reconstructive surgery. The method and compositions result in closer apposition of bone to the connective tissue at earlier time points and increased strength of fixation at earlier time points.

L'invention concerne des procédés et des compositions pour le traitement de malformations et de maladies affectant les insertions fonctionnelles du tissu conjonctif, comme par exemple les tendons et les ligaments, sur les os. Les procédés préférés consistent à administrer une composition contenant une protéine morphogénétique osseuse et un vecteur approprié. Le procédé assure une régénération des insertions fonctionnelles entre le tissu conjonctif et les os, avec formation minimale de tissu fibreux ou de granulation à l'interface entre l'os et le tissu conjonctif régénérés. Le procédé et la composition sont utiles pour améliorer les greffes tissulaires en chirurgie reconstructive. Le procédé et les compositions permettent une apposition améliorée et plus rapide de l'os et du tissu conjonctif, ainsi qu'une fixation plus rapide et plus solide.

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